3002929
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Paraneoplastic Reflexive Panel

PNS PAN2
Example Reports
Negative
Positive

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Additional Technical Information

Ordering Recommendation

Serum test to aid in the diagnosis of paraneoplastic neurologic syndromes.

This test only evaluates for the presence of high-risk paraneoplastic antibodies, independent of neurologic phenotype. Targeted phenotype-specific panels are preferred for the evaluation of autoimmune neurologic disease. Refer to the ARUP Autoimmune Neurology Panel Components tables for phenotype-specific test options.

Testing in both serum and CSF is recommended to maximize diagnostic yield; refer to Paraneoplastic Reflexive Panel, CSF (3004517) for CSF testing.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST)

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum aliquot to an ARUP standard transport tube. (Min: 1.0 mL)

Storage/Transport Temperature

Refrigerated

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or lipemic specimens

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Semi-Quantitative Cell-Based Indirect Fluorescent Antibody/Qualitative Immunoblot

Performed

Wed

Reported

1-9 days

Reference Interval

Test Number
 Components
 Reference Interval
  Neuronal Antibody (Amphiphysin) Negative
  Purkinje Cell/Neuronal Nuclear IgG Scrn None Detected
  CV2 Ab IgG CBA-IFA Screen, Serum Less than 1:100
  SOX1 Antibody, IgG by Immunoblot, Serum Negative

Interpretive Data

Refer to report

Compliance Category

Laboratory Developed Test (LDT)

Note

Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be added. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot will be added. Additional charges apply.
If CV2 Antibody IgG Screen by IFA is positive, then CV2 Antibody IgG Titer by IFA will be added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/20/2024
X
X
X
08/21/2023
X
N/A

CPT Codes

86255 x2; 84182 x2; if reflexed add 86256 and/or 84182 x4; if reflexed add 86256

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Components

Component Test Code* Component Chart Name LOINC
0051709 Neuronal Antibody (Amphiphysin) 94385-2
2007962 Purkinje Cell/Neuronal Nuclear IgG Scrn 61177-2
2013959 CV2 Ab IgG CBA-IFA Screen, Serum 72504-4
3002903 SOX1 Antibody, IgG by Immunoblot, Serum 82444-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Paraneoplastic Reflexive Panel